Liberia

SPL

CLICK HERE - RESEARCH - Nature - Toremifene interacts with and destabilizes the Ebola virus glycoprotein

bbc.com - by James Gallagher - June 30, 2016

The painkiller ibuprofen and the cancer drug toremifene can disable the Ebola virus, say researchers.

Scientists used the UK's national synchrotron facility - Diamond Light Source - to analyse the virus in incredible detail.

They revealed the two drugs could bind to the crucial part of Ebola that the virus needs to infect cells.

However, the team warns this is just a starting point and more effective drugs need to be researched.

(READ COMPLETE ARTICLE)

ADDITIONAL REFERENCES ARE PROVIDED BELOW:

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
http://www.nature.com/nature/archive/subject.html?code=326

Toremifene interacts with and destabilizes the Ebola virus glycoprotein
http://www.nature.com/subjects/ebola-virus

Spatial distribution of simulated LAS spill-over events across its endemic region in western Africa for (a) present day, and (b) projected for 2070 under a medium climate and full land cover change scenario. Values represent the expected number of spill-over events per grid cell per year, and are represented on a linear color scale where green is all simulations and grey zero. Axis labels indicate degrees, in a World Geodetic System 84 projection. Filled black circles represent locations of historic LAS outbreaks.  Credit: Redding et al. UCL

CLICK HERE - Predicting disease outbreaks using environmental changes

sciencedaily.com - June 13, 2016

A model that predicts outbreaks of zoonotic diseases -- those originating in livestock or wildlife such as Ebola and Zika -- based on changes in climate, population growth and land use has been developed by a team of researchers.

CLICK HERE -UCL - Predicting disease outbreaks using environmental changes

Humans have been “acquiring” infectious diseases from animals (zoonotic diseases) since we first started hunting wild game on the African savannahs. Indeed, nearly 60% of bugs that infect humans originated in animals.

Introduction: The 2014 Ebola outbreak in West Africa raised many questions about the control of infectious disease in an increasingly connected global society. Limited availability of contact information made contact tracing diffcult or impractical in combating the outbreak. 

Methods: We consider the development of multi-scale public health strategies that act on individual and community levels. We simulate policies for community-level response aimed at early screening all members of a community, as well as travel restrictions to prevent inter-community transmission.