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London Group Plans to Start First Clinical Tests of Ebola Drugs in West Africa

Washington Post

by Abby Ohlheiser September 23 at 11:45 AM

London based scientists, working with international aid groups, are planning to start the first clinical trials in West Africa for drugs to treat Eboa. The trials could begin in a matter of months.

Wellcome Trust's $5 million initiative will include drugs from Mapp Biopharmaceutical, Sarepta and Tekmira, according to Reuters. Mapp makes zMapp, the experimental cocktail administered to two Americans who contracted the disease in Liberia. Tekmira recently gained the approval of the U.S. Food and Drug Administration to use its TKM-Ebola treatment on confirmed or suspected cases of the disease.

Both drugs are still in the experimental phase; researchers have not yet determined the safety or effectiveness of the treatments.

Text of full story:

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EBOLA MAY BECOME ENDEMIC TO WEST AFRICA WITH 71 PER CENT INFECTION RATE--WHO STUDY

LOS ANGLES TIMES     September 22, 10:25 PM

by Monte Morin

In a grim assessment of the Ebola epidemic, researchers say the deadly virus threatens to become endemic to West Africa instead of eventually disappearing from humans.

"The current epidemiologic outlook is bleak," wrote a panel of more than 60 World Health Organization experts in a study published Tuesday by the New England Journal of Medicine.

"We must therefore face the possibility that Ebola virus disease will become endemic among the human population of West Africa, a prospect that has never previously been contemplated."

In the absence of new control measures, the authors estimated that the total case load would exceed 20,000 by Nov 2.

Link to full story

http://www.latimes.com/science/sciencenow/la-sci-sn-ebola-may-be-endemic-in-people-20140922-story.html

Link to New England Journal of Medicine study

http://www.nejm.org/doi/full/10.1056/NEJMoa1411100?query=featured_ebola

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Ebola in Africa: Chaos is contagious

Illustration: Ebola virus (Photo: Thinkstock.com)courier-journal.com/The Chigaco Tribune - Sep 22, 2014

Faced with a brutal and wily adversary, President Barack Obama on Tuesday ordered a scaled-up military assault. Not on terrorists in Syria, but Ebola in West Africa.

The president dispatched some 3,000 American troops to help build 17 treatment centers. The Pentagon will establish a military command center in Liberia to coordinate the civilian response to the epidemic. American military health experts will help train thousands of African health care workers. American aid workers will help distribute supplies and information to families there.

The U.S. — and, we hope, the rest of the world — is getting serious about confronting this plague blazing through Africa. The official Ebola toll as of late Tuesday: 4,985 cases and 2,461 deaths. Some experts, however, suspect the actual death tally is much higher. And the rate of Ebola infection is growing exponentially. The number of Ebola cases could spike to 20,000 in a matter of months.

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Sierra Leone Medical Team attacked

 

 

FREETOWN, Sun Sep 21, 2014 Reuters

 

 
 
 

1 of 2. Medical staff working with Medecins sans Frontieres (MSF) prepare to bring food to patients kept in an isolation area at the MSF Ebola treatment centre in Kailahun July 20, 2014.

Credit: Reuters/Tommy Trenchard

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Upcoming CDC estimate reportedly predicts up to 500,000 Ebola victims - Leaked

Washington Post, September 20
 

The Ebola epidemic sweeping West Africa could infect up to 500,000 people by the end of January, according to a new estimate under development by the Centers for Disease Control and Prevention.

The report is scheduled to be released next week, but work on it is still ongoing and projections could change, said a person who is familiar with its contents but was not authorized to speak because the report is not yet public.

Sierra Leone begins three-day lockdown to counter Ebola

FREETOWN, Sierra Leone — One of the most stringent anti-Ebola measures to date began here Friday morning as Sierra Leone imposed a three-day national lockdown, ordering people off the streets and into their homes in an effort to stamp out the deadly disease.

Police officers patrolled the streets of the densely populated capital, telling stragglers to go home and stay indoors. Volunteers in bright jerseys prepared to go house-to-house throughout the country to warn people about Ebola’s dangers and to root out those who might be infected but were staying in hiding.

The normally busy streets of Freetown were empty Friday morning, stores were closed and pedestrians were rare on the main thoroughfares.

The country’s president, justifying the extraordinary move in a radio address Thursday night, suggested that Sierra Leone was engaged in a life-or-death struggle with the disease.

U.S. Public Health Service Commissioned Corps to Help Treat Ebola Patients in Liberia

                               

hhs.gov - September 16, 2014

A team of specialized officers from the U.S. Public Health Service Commissioned Corps is being prepared to deploy to manage and staff a previously announced U.S. Department of Defense hospital in Liberia to care for health care workers who become ill from Ebola.

The U.S. Public Health Service Commissioned Corps is part of the U.S. Department of Health and Human Services. The Commissioned Corps is an elite uniformed service with more than 6,800 full-time, highly qualified public health professionals, serving the most underserved and vulnerable populations domestically and abroad.

Sixty-five Commissioned Corps officers, with diverse clinical and public health backgrounds, will travel to Liberia to provide direct patient care to health care workers. In addition to their professional expertise, these officers will undergo further intensive training in Ebola response and advanced infection control.

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UN Announces Mission to Combat Ebola, Declares Outbreak ‘Threat to Peace and Security’

un.org

18 September 2014 – The Security Council, in its first emergency meeting on a public health crisis, today declared the Ebola outbreak in West Africa a threat to peace and security, as Secretary-General Ban Ki-moon announced that the United Nations will deploy a new emergency health mission to combat one of most horrific diseases on the planet that has shattered the lives of millions.

“This international mission, to be known as the United Nations Mission for Ebola Emergency Response, or UNMEER, will have five priorities: stopping the outbreak, treating the infected, ensuring essential services, preserving stability and preventing further outbreaks,” Mr. Ban told the Security Council.

“Under the leadership of a Special Representative of the Secretary-General, the Mission will bring together the full range of UN actors and expertise in support of national efforts,” he said, adding that details of the mission were sent in a letter to the Security Council and the UN General Assembly.

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